Marco Borghi
Head of Medical Management
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This approach led to the discovery of a unique inflammatory KC subpopulation in pemphigus skin lesions. Exclusively localized in the spinous layer and characterized by high CCL19 expression, inflammatory KCs engage in robust interactions with DCs and B cells through the CCL19–CCR7 axis, underscoring their potential role in promoting autoimmunity in pemphigus
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Marco Borghi
Head of Medical Management
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#World Medical Association Declaration of HelsinkiThe primary purpose of medical research involving human participants is to generate knowledge to understand the causes, development, and effects of diseases; improve preventive, diagnostic, and therapeutic interventions; and ultimately to advance individual and public health.These purposes can never take precedence over the rights and interests of individual research participants.
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Marco Borghi
Head of Medical Management
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Melanoma progression involves genetic, epigenetic, and molecular changes in both tumor cells and the surrounding tumor microenvironment (TME), particularly dermal fibroblasts (dFs).Aging alters these fibroblasts, affecting their secretion of factors and proteins, which can promote tumor growth, invasion, and resistance to therapy.Aging promotes a decline in CD9 expression in dermal fibroblast extracellular vesiclesLoss of CD9 drives secretion of the angiogenesis promotor ANGPTL2 in extracellular vesiclesExtracellular vesicles increase angiogenesis in melanoma in an age-dependent manner.
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Marco Borghi
Head of Medical Management
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Study underscores the genetic complexity of the human gut microbiota, emphasizing its significant implications for host health.High strain-level variability associates with species’ capacity to sporulateExtreme antibiotic resistance is widespread in the healthy, non-hospitalized populationThe presence of specific microbial genes relates to host age and sexThe pangenomes and antibiotic resistance map constitute a valuable resource for further research.
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Marco Borghi
Head of Medical Management
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The 50-by-50 goal, with an interim milestone of a 30% reduction in the probability of premature death by 2035, remains within reach. The most efficient route is to focus resources against a narrow set of conditions and scale up financing to develop and deploy new health technologies. Analyses have shown that the economic value of achievable mortality declines is high and is often a substantial fraction of the value of gains from economic growth itself. The case is better than ever for the value of investing in health for reducing mortality and morbidity, alleviating poverty, growing economies, and improving human welfare.
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Marco Borghi
Head of Medical Management
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#No one should face breast cancer aloneBreast cancer, one of the most common cancers globally, claimed 670,000 lives in 2022and was the most frequent cancer among women in 157 of 185 countries. According to the World Health Organization (WHO), 2.3 million women were diagnosed with breast cancer in 2022 alone. Although significant advances in medical treatments have improved survival rates, the impact of a diagnosis extends beyond physical symptoms. It can profoundly affect a person’s sense of identity, security, and well-being.
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Marco Borghi
Head of Medical Management
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Exposure to the low levels of pesticides examined here may disrupt thyroid homeostasis in humans.
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Marco Borghi
Head of Medical Management
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In this study, child tablet use at age 3.5 years was associated with more expressions of anger and frustration by the age of 4.5 years. Child proneness to anger/frustration at age 4.5 years was then associated with more use of tablets by age 5.5 years. These results suggest that early-childhood tablet use may contribute to a cycle that is deleterious for emotional regulation.
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Marco Borghi
Head of Medical Management
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We are exposed to hundreds, possibly thousands, of chemicals in our daily lives. The exposome encompasses all environmental factors that influence human well-being throughout life, such as lifestyle, chemical exposures, and social pressures, and is widely recognized as being relevant to triggering or accelerating disease. The toxic exposome is of particular interest, as there is a positive correlation between the increasing number of chemicals produced and adverse outcomes, such as the increasing prevalence of noncommunicable diseases as well as behavioral disorders. Further, the exposure to endocrine disrupting or neurotoxic chemicals has been directly associated with impacts on the neurodevelopment of children.
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